Study on the Characteristics of Small-Molecule Kinase Inhibitors-Related Drug-Induced Liver Injury.

ABSTRACT: Background and Aim: More than half of the small-molecule kinase inhibitors (KIs) induced liver injury clinically. Meanwhile, studies have shown a close relationship between mitochondrial damage and drug-induced liver injury (DILI). We aimed to study KIs and the binding between drugs and mitochondrial proteins to find factors related to DILI occurrence. Methods: A total of 1,223 oral FDA-approved drugs were collected and analyzed, including 44 KIs. Fisher's exact test was used to analyze DILI potential and risk of different factors. A total of 187 human mitochondrial proteins were further collected, and high-throughput molecular docking was performed between human mitochondrial proteins and drugs in the data set. The molecular dynamics simulation was used to optimize and evalu

SUBMITTER: Dong H 

PROVIDER: S-EPMC9068902 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature