Fasting Insulin and Risk of Overall and 14 Site-Specific Cancers: Evidence From Genetic Data.

ABSTRACT:

Objective

Whether fasting insulin (FI) plays a role in cancer risk remains unclear. This study aimed to investigate the association between FI and cancer risk and to explore its potential mediator role in the association between type 2 diabetes mellitus (T2DM) and cancer.

Methods

Two-sample Mendelian randomization (TSMR) analysis was performed to evaluate the effect of FI on overall and 14 site-specific cancers using genome-wide association study (GWAS) summary-level data from Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) and consortia of 14 site-specific cancers. The primary MR approach was conducted by using the random-effect inverse-variance weighted (IVW) method, and sensitivity analyses were implemented by adopting weighted-median, weighted-mode

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9069016 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature