The genomic signatures of natural selection in admixed human populations.

ABSTRACT: Admixture has been a pervasive phenomenon in human history, extensively shaping the patterns of population genetic diversity. There is increasing evidence to suggest that admixture can also facilitate genetic adaptation to local environments, i.e., admixed populations acquire beneficial mutations from source populations, a process that we refer to as "adaptive admixture." However, the role of adaptive admixture in human evolution and the power to detect it remain poorly characterized. Here, we use extensive computer simulations to evaluate the power of several neutrality statistics to detect natural selection in the admixed population, assuming multiple admixture scenarios. We show that statistics based on admixture proportions, F_adm and LAD, show high power to detect mutations

SUBMITTER: Cuadros-Espinoza S 

PROVIDER: S-EPMC9069077 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature