Micronutrient supplementation and pregnancy outcomes: double-blind randomized controlled trial in China.

ABSTRACT:

Background

Beyond perinatal folic acid supplementation, the need for additional prenatal prophylaxis of iron with or without other micronutrients remains unclear. We aim to investigate the maternal and infant health effects of iron plus folic acid and multiple micronutrient supplements vs folic acid alone when provided to pregnant women with no or mild anemia.

Methods

In this randomized double-blind controlled trial, 18,775 nulliparous pregnant women with mild or no anemia were enrolled from 5 counties of northern China from May 2006 through April 2009. Women were randomly assigned to daily folic acid (400 μg) (control), folic acid-iron (30 mg), or folic acid, iron, and 13 additional vitamins and minerals provided before 20 weeks gestation to delivery. Primary outcome was pe

SUBMITTER: Liu JM 

PROVIDER: S-EPMC9069205 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature