Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.

ABSTRACT: Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A-I (1-9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A-I (1-9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity.

SUBMITTER: Nugroho AE 

PROVIDER: S-EPMC9069220 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature