Impact of Antibiotic Resistance Genes in Gut Microbiome of Patients With Cirrhosis.

ABSTRACT:

Background and aims

Cirrhosis is associated with changes in intestinal microbiota that can lead to hepatic encephalopathy (HE) and infections, especially with antibiotic-resistant organisms. However, the impact of gut microbial antibiotic resistance gene (ARG) burden on clinical outcomes is unclear. The aims of the study were to determine the impact of ARGs in cirrhosis-related gut metagenome on outcomes and disease progression, study the effect of rifaximin on ARG burden, and compare ARGs in cirrhosis with chronic kidney disease (CKD) and diabetes.

Methods

In outpatients with cirrhosis who underwent metagenomics, we evaluated change in ARG abundances with progression and their multivariable impact on 90-day hospitalizations and deaths over 1 year. We also studied ARGs pre-

SUBMITTER: Shamsaddini A 

PROVIDER: S-EPMC9069394 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature