Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis.

ABSTRACT:

Objectives

Rheumatoid arthritis (RA) is an autoimmune disease, associated with chronic inflammation of synoviocytes. Tumor necrosis factor α (TNF-α) plays a crucial role in the pathogenesis of RA through pro-inflammatory cytokines. Nicotine, an alkaloid used as herbal medicine, often worked as an anti-inflammatory agent. In the present study, we tried to uncover the anti-inflammatory impact of nicotine against RA.

Materials and methods

Nicotine was isolated from Brassica oleracea, purified by high profile/phase liquid chromatography (HPLC). In-silico docking was carried out using bioinformatics tools SwissADME (absorption, distribution, metabolism and excretion), PASS, and Drug-induced Gene Expression Profile (DIGEP)-Pred to determine drug likeliness of nicotine. The in-vitr

SUBMITTER: Rakhecha B 

PROVIDER: S-EPMC9069442 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature