3D printable SiO₂ nanoparticle ink for patient specific bone regeneration.

ABSTRACT: Sodium alginate and gelatin are biocompatible & biodegradable natural polymer hydrogels, which are widely investigated for application in tissue engineering using 3D printing and 3D bioprinting fabrication techniques. The major challenge of using hydrogels for tissue fabrication is their lack of regeneration ability, uncontrolled swelling, degradation and inability to hold 3D structure on their own. Free hydroxyl groups on the surface of SiO₂ nanoparticles have the ability to chemically interact with alginate-gelatin polymer network, which can be explored to achieve the above parameters. Hence validating the incorporation of SiO₂ nanoparticles in a 3D printable hydrogel polymer network, according to the patient's critical defects has immense scope in bone tissue engin

SUBMITTER: Roopavath UK 

PROVIDER: S-EPMC9069463 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature