Sleep disturbance and psychiatric disorders: a bidirectional Mendelian randomisation study.

ABSTRACT:

Aims

Sleep disturbance is an important factor in the pathophysiology and progression of psychiatric disorders, but whether it is a cause, or a downstream effect is still not clear.

Methods

To investigate causal relationships between three sleep-associated traits and seven psychiatric diseases, we used genetic variants related to insomnia, chronotype and sleep duration to perform a two-sample bidirectional Mendelian randomisation analysis. Summary-level data on psychiatric disorders were extracted from the Psychiatric Genomics Consortium. Effect estimates were obtained by using the inverse-variance-weighted (IVW), weights modified IVW, weighted-median methods, MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO) test and Robust Adjusted Profile Score (RAPS)

SUBMITTER: Sun X 

PROVIDER: S-EPMC9069588 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature