Reflecting on the utility of standardized uptake values on ¹⁸F-FDG PET in nasopharyngeal carcinoma.

ABSTRACT:

Background

To rethink the clinical significance of standardized uptake values (SUVs) of nasopharyngeal carcinoma (NPC) on ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron-emission tomography (PET).

Methods

We retrospectively reviewed 369 NPC patients who underwent pretreatment ¹⁸F-FDG PET. The predictive value of the SUVmax of the primary tumor (SUVmax-t) and regional lymph nodes (SUVmax-n) was evaluated using probability density functions. Receiver operating characteristic curves were used to determine optimal cutoffs for the SUVmax-n/SUVmax-t ratio (NTR). Kaplan-Meier and Cox regression analyses were used to assess survival.

Results

The optimal SUVmax-t and SUVmax-n cutoffs were 7.5 and 6.9, respectively. High SUVmax-t and SUVmax-n were rel

SUBMITTER: Qiu X 

PROVIDER: S-EPMC9069730 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature