Shared genetic links between frontotemporal dementia and psychiatric disorders.

ABSTRACT:

Background

Epidemiological and clinical studies have suggested comorbidity between frontotemporal dementia (FTD) and psychiatric disorders. FTD patients carrying specific mutations were at higher risk for some psychiatric disorders, and vice versa, implying potential shared genetic etiology, which is still less explored.

Methods

We examined the genetic correlation using summary statistics from genome-wide association studies and analyzed their genetic enrichment leveraging the conditional false discovery rate method. Furthermore, we explored the causal association between FTD and psychiatric disorders with Mendelian randomization (MR) analysis.

Results

We identified a significant genetic correlation between FTD and schizophrenia at both genetic and transcriptomic leve

SUBMITTER: Li C 

PROVIDER: S-EPMC9069762 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature