Comprehensive molecular characterization of hypertension-related genes in cancer.

ABSTRACT:

Background

During cancer treatment, patients have a significantly higher risk of developing cardiovascular complications such as hypertension. In this study, we investigated the internal relationships between hypertension and different types of cancer.

Methods

First, we comprehensively characterized the involvement of 10 hypertension-related genes across 33 types of cancer. The somatic copy number alteration (CNA) and single nucleotide variant (SNV) of each gene were identified for each type of cancer. Then, the expression patterns of hypertension-related genes were analyzed across 14 types of cancer. The hypertension-related genes were aberrantly expressed in different types of cancer, and some were associated with the overall survival of patients or the cancer stage. Subse

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9069779 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature