The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study.

ABSTRACT:

Objective

To explore the impact of pre-pregnancy vaginal Mycoplasma hominis (M. hominis) colonization of low abundance on female fecundability.

Methods

In total, 89 females participating in a pre-pregnancy health examination program were included, and their pregnancy outcomes were followed up for 1 year. Vaginal swabs were collected, 16S rRNA genes were sequenced, and M. hominis colonization was confirmed by qPCR. Cox models were used to estimate the fecundability odds ratio (FOR) for women with M. hominis.

Results

The prevalence of M. hominis was 22.47% (20/89), and the abundance was relatively low (the cycle thresholds of the qPCR were all more than 25). In terms of the vaginal microbiome, the Simpson index of the positive group was significantly lower than that of

SUBMITTER: Hong X 

PROVIDER: S-EPMC9069813 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature