Tete-a-tete with CtBP dimers.
Ontology highlight
ABSTRACT:
SUBMITTER: Raicu AM
PROVIDER: S-EPMC9069854 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Tête-à-tête with CtBP dimers.
Raicu Ana-Maria AM Bird Kalynn M KM Arnosti David N DN
Structure (London, England : 1993) 20210401 4
Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration. ...[more]
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