Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate.

ABSTRACT: A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by ¹H-NMR, ¹³C-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC₅₀ value of 11.4 μg mL^-1, which is significantly superior to those of bismerthiazol (BT) (51.6 μg mL^-1) and thiodiazole-copper (TC) (94.7 μg mL^-1). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with

SUBMITTER: Guo T 

PROVIDER: S-EPMC9069940 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature