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Detailed structural and spectroscopic elucidation of ferrocenium coupled N-heterocyclic carbene gold(I) complexes.

ABSTRACT: Unambiguous assignment of redox sites on ferrocene coupled N-heterocyclic carbene gold(I) complexes [(Fc-NHC)₂Au(I)]⁺ is critical to gain a greater mechanistic understanding of their activity in a cellular environment. Such information can be garnered with isolation and detailed characterization of the oxidized version of [(Fc-NHC)₂Au(I)]⁺. Herein we disclose a study that unambiguously illustrates redox events pertaining to [(Fc-NHC)₂Au(I)]⁺ that stem exclusively from ferrocene sites. This work also describes novel synthetic methodologies for isolating ferrocenium coupled N-heterocyclic carbene gold(I) complexes.

SUBMITTER: Reinhard GL

PROVIDER: S-EPMC9069980 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Detailed structural and spectroscopic elucidation of ferrocenium coupled N-heterocyclic carbene gold(I) complexes.

Reinhard Garrett L GL Jayaraman Selvakumar S Prybil Joshua W JW Arambula Jonathan F JF Arumugam Kuppuswamy K

Dalton transactions (Cambridge, England : 2003) 20220125 4

Unambiguous assignment of redox sites on ferrocene coupled N-heterocyclic carbene gold(I) complexes [(Fc-NHC)2Au(I)]+ is critical to gain a greater mechanistic understanding of their activity in a cellular environment. Such information can be garnered with isolation and detailed characterization of the oxidized version of [(Fc-NHC)2Au(I)]+. Herein we disclose a study that unambiguously illustrates redox events pertaining to [(Fc-NHC)2Au(I)]< ...[more]

PMID: 34989720

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