The vaginal microbiome in women of reproductive age with healthy weight versus overweight/obesity.

ABSTRACT:

Objective

The aim of this study was to evaluate the differences between the vaginal microbiome of reproductive-aged women with overweight and obesity (Ow/Ob) compared with healthy weight (HW).

Methods

In this case-control study, a cohort of 367 nonpregnant women (18 to 40 years) with Ow/Ob (BMI ≥25 kg/m² ) was case-matched with 367 women with HW (BMI 18.0 to 24.9 kg/m² ). The study was a secondary analysis of 16S rRNA vaginal microbiome surveys through the Vaginal Human Microbiome Study (VaHMP). Groups were matched on age, race/ethnicity, income, and nulliparity status.

Results

Mean age and BMI of Ow/Ob and HW groups were 26.8 versus 26.7 years and 37.0 versus 22.1 kg/m² , respectively. The overall vaginal microbiome composition differ

SUBMITTER: Allen NG 

PROVIDER: S-EPMC9070090 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature