The hydrogenation of mandelonitrile over a Pd/C catalyst: towards a mechanistic understanding.

ABSTRACT: A carbon supported Pd catalyst is used in the liquid phase hydrogenation of the aromatic cyanohydrin mandelonitrile (C₆H₅CH(OH)CH₂CN) to afford the primary amine phenethylamine (C₆H₅CH₂CH₂NH₂). Employing a batch reactor, the desired primary amine is produced in 87% selectivity at reaction completion. Detection of the by-product 2-amino-1-phenylethanol (C₆H₅CH(OH)CH₂NH₂) accounts for the remaining 13% and closes the mass balance. The reaction mechanism is investigated, with a role for both hydrogenation and hydrogenolysis processes established.

SUBMITTER: McAllister MI 

PROVIDER: S-EPMC9070305 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature