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The synthesis of a ^99mTc-labeled tetravalent targeting probe upon isonitrile coordination to ^99mTc^I for enhanced target uptake in saturable systems.

ABSTRACT: The presence of excess unlabeled ligands in the injectate hinders the target uptake of ^99mTc-labeled targeting vectors. To address the issue, we previously developed a chemical design which provides a ^99mTc-labeled trivalent RGD probe upon CN-βAla-Gly-Gly-c(RGDfK) (L_β) coordination to [^99mTc][Tc(CO)₃]⁺ core at pH 6.0. In this study, we extended our coordination mediated synthesis of the trivalent RGD probe to that of a tetravalent one. Our initial attempts reacting L_β with [^99mTc][Tc(CO)₃]⁺ core at pH 8.0 failed to provide [^99mTc][Tc(CO)₂(L_β)₄]⁺ due to the formation of multiple side products. A γ-aminobutylic acid (GABA) based

SUBMITTER: Mizuno Y

PROVIDER: S-EPMC9070385 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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The synthesis of a ^99mTc-labeled tetravalent targeting probe upon isonitrile coordination to ^99mTc^I for enhanced target uptake in saturable systems.

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Dataset Information

The synthesis of a 99mTc-labeled tetravalent targeting probe upon isonitrile coordination to 99mTcI for enhanced target uptake in saturable systems.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The synthesis of a ^99mTc-labeled tetravalent targeting probe upon isonitrile coordination to ^99mTc^I for enhanced target uptake in saturable systems.