Fluorescent delivery vehicle containing cobalt oxide-umbelliferone nanoconjugate: DNA/protein interaction studies and anticancer activity on MF7 cancer cell line.

ABSTRACT: Fluorescent labeling is limited to certain molecules and alters biomolecule functionality. A new class of nanomaterial with anticancer activity and fluorescence properties has been designed and prepared. This nanotherapeutic conjugate of natural molecules has a selective binding site in cancer cell lines. Natural drug umbelliferone was taken with cobalt metal ions in a one pot assembly in the presence of tannic acid which yields new fluorescent nanoparticles of umbelliferone cobalt oxide nanoconjugate. Umbelliferone has high fluorescent properties and also has coordination ability to bind with central metal ions. The nanoconjugate was synthesized and characterized by using TEM, EDX analysis, SEM, XRD, and FTIR spectroscopy. TEM shows that the average size of the particles formed with umbel

SUBMITTER: Ali MS 

PROVIDER: S-EPMC9070427 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature