The expression and role of tenascin C in abdominal aortic aneurysm formation and progression.

ABSTRACT:

Objectives

Up-regulation of tenascin C (TNC), a matricellular protein, produced mainly by vascular smooth muscle cells (VSMC), is associated with the progression and dilation of abdominal aortic aneurysms (AAA). The aims of this study were (i) to evaluate whether serum levels of TNC in patients with AAA patients correlate with aortic diameter and (ii) to clarify the role of TNC in formation and progression of AAA in a murine model.

Methods

In 15 patients with AAA serum levels of TNC were measured and correlated with aortic diameters. Moreover, in a murine calcium chloride AAA model, the impact of TNC deficiency on AAA diameter was evaluated. Finally, human VSMC were incubated with TNC to clarify its regulating potential.

Results

In the clinical cohort, there was a tre

SUBMITTER: Nagel F 

PROVIDER: S-EPMC9070497 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature