Time-dependent mechanical behaviour of the aortic chronic dissection flap.

ABSTRACT:

Objectives

The transition of aortic dissection from acute to chronic is poorly understood. We examined time-dependent mechanical behaviour and biochemical properties of chronic dissection tissues.

Methods

Aorta samples were obtained from 14 patients with mixed aetiology who were undergoing elective surgery for chronic dissected aneurysms, ranging from 3 months to 15 years post-dissection. The tissue elastic modulus and tissue deformation following application of loading for 5 h were measured for the false lumen (FL), true lumen (TL) and flap (FP) tissues with a custom-indentation technique. Collagen, elastin and glycosaminoglycan levels were determined with established biochemical assays. Elastin fragmentation was graded from histological sections. The number of tissues char

SUBMITTER: Panpho P 

PROVIDER: S-EPMC9070530 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature