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One-step construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide via a cascade reaction sequence.

ABSTRACT: A concise and versatile method for the construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide has been achieved in DMSO without addition of extra reagents. The present protocol is compatible with various secondary amines and primary amines, and suitable for intermolecular and intramolecular reactions. Diverse unsymmetrical thioureas and oxazolidinethiones were efficiently obtained in good to excellent yields via a cascade reaction sequence.

SUBMITTER: Ding C

PROVIDER: S-EPMC9070531 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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One-step construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide <i>via</i> a cascade reaction sequence.

Ding Chaochao C Wang Shaoli S Sheng Yaoguang Y Dai Qian Q Zhao Yunjie Y Liang Guang G Song Zengqiang Z

RSC advances 20190827 46

A concise and versatile method for the construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide has been achieved in DMSO without addition of extra reagents. The present protocol is compatible with various secondary amines and primary amines, and suitable for intermolecular and intramolecular reactions. Diverse unsymmetrical thioureas and oxazolidinethiones were efficiently obtained in good to excellent yields <i>via</i> a cascade reaction sequence. ...[more]

PMID: 35528578

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