Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer.

ABSTRACT: Nanocarriers have emerged as one of the most promising approaches for drug delivery. Although several nanomaterials have been approved for clinical use, the translation from lab to clinic remains challenging. However, by implementing rational design strategies and using relevant models for their validation, these challenges are being addressed. This work describes the design of novel immunocompatible polymer nanocarriers made of melanin-mimetic polydopamine and Pluronic F127 units. The nanocarrier preparation was conducted under mild conditions, using a highly reproducible method that was tuned to provide a range of particle sizes (<100 nm) without changing the composition of the carrier. A set of in vitro studies were conducted to provide a comprehensive assessment of the effect of

SUBMITTER: Popov AB 

PROVIDER: S-EPMC9070568 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature