ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB₁ Receptors.

ABSTRACT: Introduction: Activation of cannabinoid 1 receptors (CB₁Rs) by endocannabinoids (eCBs) is controlled by both eCB production and eCB inactivation. Accordingly, inhibition of eCB hydrolyzing enzymes, monoacylglycerol lipase (MAGL) and α/β-hydrolase domain containing 6 (ABHD6), enhances eCB accumulation and CB₁R activation. It is known that inhibition of MAGL regulates select CB₁R-dependent behaviors in mice, including locomotor behaviors and their modulation by psychostimulants, but much less is known about the effect of inhibiting ABHD6 activity on such behaviors. Methods: We report a new mouse line that carries a genetic deletion of Abhd6 and evaluated its effect on spontaneous locomotion measured in a home cage monitoring system, motor

SUBMITTER: Deng L 

PROVIDER: S-EPMC9070749 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature