Metal-free oxidative cross-dehydrogenative coupling of quinones with benzylic C(sp³)-H bonds.

ABSTRACT: A metal-free cross-dehydrogenative coupling of quinones with toluene derivatives has been established. A series of quinones were subjected to reaction with toluene derivatives in the presence of di-tertbutyl peroxide (DTBP) for direct synthesis of benzylquinones. The method exhibits good functional group tolerance, and desired products were obtained in moderate to good yields. Meanwhile, a radical pathway was proposed to describe the cross-dehydrogenative coupling of quinones with toluene derivatives.

SUBMITTER: Dong Y 

PROVIDER: S-EPMC9070767 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature