Enrichment of Non-B-Form DNA at D. melanogaster Centromeres.

ABSTRACT: Centromeres are essential chromosomal regions that mediate the accurate inheritance of genetic information during eukaryotic cell division. Despite their conserved function, centromeres do not contain conserved DNA sequences and are instead epigenetically marked by the presence of the centromere-specific histone H3 variant centromeric protein A. The functional contribution of centromeric DNA sequences to centromere identity remains elusive. Previous work found that dyad symmetries with a propensity to adopt noncanonical secondary DNA structures are enriched at the centromeres of several species. These findings lead to the proposal that noncanonical DNA structures may contribute to centromere specification. Here, we analyze the predicted secondary structures of the recently identified centr

SUBMITTER: Patchigolla VSP 

PROVIDER: S-EPMC9070824 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature