Warfarin sensitivity is associated with increased hospital mortality in critically Ill patients.

ABSTRACT:

Background

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in the therapeutic dose. Warfarin sensitivity has been reported to be associated with increased incidence of international normalized ratio (INR) > 5. However, whether warfarin sensitivity is a risk factor for adverse outcomes in critically ill patients remains unknown. In the present study, we aimed to evaluate the utility of different machine learning algorithms for the prediction of warfarin sensitivity and to determine the impact of warfarin sensitivity on outcomes in critically ill patients.

Methods

Nine different machine learning algorithms for the prediction of warfarin sensitivity were tested in the International Warfarin Pharmacogenetic Consortium co

SUBMITTER: Ma Z 

PROVIDER: S-EPMC9070894 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature