Do multiple experimenters improve the reproducibility of animal studies?

ABSTRACT: The credibility of scientific research has been seriously questioned by the widely claimed "reproducibility crisis". In light of this crisis, there is a growing awareness that the rigorous standardisation of experimental conditions may contribute to poor reproducibility of animal studies. Instead, systematic heterogenisation has been proposed as a tool to enhance reproducibility, but a real-life test across multiple independent laboratories is still pending. The aim of this study was therefore to test whether heterogenisation of experimental conditions by using multiple experimenters improves the reproducibility of research findings compared to standardised conditions with only one experimenter. To this end, we replicated the same animal experiment in 3 independent laboratories, each emplo

SUBMITTER: von Kortzfleisch VT 

PROVIDER: S-EPMC9070896 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature