Estimating heterogeneity of physical function treatment response to caloric restriction among older adults with obesity.

ABSTRACT: Clinical trials conventionally test aggregate mean differences and assume homogeneous variances across treatment groups. However, significant response heterogeneity may exist. The purpose of this study was to model treatment response variability using gait speed change among older adults participating in caloric restriction (CR) trials. Eight randomized controlled trials (RCTs) with five- or six-month assessments were pooled, including 749 participants randomized to CR and 594 participants randomized to non-CR (NoCR). Statistical models compared means and variances by CR assignment and exercise assignment or select subgroups, testing for treatment differences and interactions for mean changes and standard deviations. Continuous equivalents of dichotomized variables were also fit. Models us

SUBMITTER: Beavers DP 

PROVIDER: S-EPMC9070937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature