Brain differential gene expression and blood cross-validation of a molecular signature of patients with major depressive disorder.

ABSTRACT:

Introduction

The agreement between clinicians diagnosing major depressive disorder (MDD) is poor. The objective of this study was to identify a reproducible and robust gene expression marker capable of differentiating MDD from healthy control (HC) subjects.

Materials and methods

Brain and blood gene expression datasets were searched, which included subjects with MDD and HC. The largest database including different areas of brain samples (GSE80655) was used to identify an initial gene expression marker. Tests of robustness and reproducibility were then implemented in 13 brain and 7 blood independent datasets. Correlations between expression in brain and blood samples were also examined. Finally, an enrichment analysis to explore the marker biological meaning was completed.

SUBMITTER: Gomez Rueda H 

PROVIDER: S-EPMC9071037 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature