Synthesis of a 1,2-cis-indoxyl galactoside as a chromogenic glycosidase substrate.

ABSTRACT: A synthetically challenging 1,2-cis-indoxyl galactoside, X-α-galactoside, was first prepared in this study using a cyclic ketone indoxyl acceptor and a glycosyl trichloroacetimidate donor to produce an enol glycoside and a 4,6-O-di-tert-butylsilylene-protected galactosyl donor to complete the synthesis. The target compound shows enzyme activity in the presence of α-galactosidase.

SUBMITTER: Nagata S 

PROVIDER: S-EPMC9071174 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature