Hydrocinnamic acid produced by Enterobacter xiangfangensis impairs AHL-based quorum sensing and biofilm formation in Pseudomonas aeruginosa.

ABSTRACT: Many of the Gram-negative bacteria regulate their virulence through an AHL-mediated quorum sensing (QS) mechanism. Disruption of this signaling mechanism might be a novel strategy to suppress bacterial virulence. In this report, foodborne bacterial isolates were tested for their QS-inhibitory properties using biosensor strain Chromobacterium violaceum CV026 and the extracted potential active components were evaluated for anti-QS and antibiofilm activity against pathogenic bacteria. The cell-free supernatant of Enterobacter xiangfangensis PUFSTI26 inhibited violacein production in the reporter strain and exhibited a significant reduction in extracellular virulence factors like biofilm formation, pyocyanin production, and motility of Pseudomonas aeruginosa. Characterizat

SUBMITTER: Sharma S 

PROVIDER: S-EPMC9071187 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature