Incidence and familial risk of premature ovarian insufficiency in the Finnish female population.

ABSTRACT:

Study question

What is the incidence of premature ovarian insufficiency (POI), has the incidence of POI changed over time, and what is the risk of POI among relatives of POI women?

Summary answer

The incidence of POI increased among females aged 15-19 years from 2007 onwards and decreased in older age groups, and among relatives of women with POI the risk of POI is significantly increased.

What is known already

So far, there has been no good quality, nationwide studies of the incidence of POI. Early menopause has been associated with the elevated risk of early menopause among relatives, but the knowledge of the familial risk of POI is scarce. Lower socioeconomic status has been associated with lower age at natural menopause.

Study design, size, duration

Populat

SUBMITTER: Silven H 

PROVIDER: S-EPMC9071220 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature