Dose-Response Relationships Between Polypharmacy and All-Cause and Cause-Specific Mortality Among Older People.

ABSTRACT:

Background

Although medicines are prescribed based on clinical guidelines and expected to benefit patients, both positive and negative health outcomes have been reported associated with polypharmacy. Mortality is the main outcome, and information on cause-specific mortality is scarce. Hence, we investigated the association between different levels of polypharmacy and all-cause and cause-specific mortality among older adults.

Method

The English Longitudinal Study of Ageing is a nationally representative study of people aged 50+. From 2012/2013, 6 295 individuals were followed up to April 2018 for all-cause and cause-specific mortality. Polypharmacy was defined as taking 5-9 long-term medications daily and heightened polypharmacy as 10+ medications. Cox proportional hazards re

SUBMITTER: Huang YT 

PROVIDER: S-EPMC9071388 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature