Ontology highlight
ABSTRACT:
SUBMITTER: Zakharova VV
PROVIDER: S-EPMC9071401 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20220501 8
Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark of many pathologies such as cancers, since causing the affection of the epigenome and transcriptional reprogramming. Here, we demonstrate that a loss-of-function mutation (LOF) of the major histone lysine methyltransferase SETDB1 possessing oncogenic activity in lung cancer cells leads to broad changes in the overall architecture and mechanical properties of the nucleus through genome-wide redistribution of ...[more]