Statins and Cognitive Decline in the Cardiovascular Health Study: A Comparison of Different Analytical Approaches.

ABSTRACT:

Background

Despite their well-established benefits for the prevention of cardiovascular disease, robust evidence on the effects of statins on cognition is largely inconclusive. We apply various study designs and analytical approaches to mimic randomized controlled trial effects from observational data.

Methods

We used observational data from 5 580 participants enrolled in the Cardiovascular Health Study from 1989/1990 to 1999/2000. We conceptualized the cohort as an overlapping sequence of nonrandomized trials. We compared multiple selection (eligible population, prevalent users, new users) and analytic approaches (multivariable adjustment, inverse-probability treatment weights, propensity score matching) to evaluate the association between statin use and 5-year change in gl

SUBMITTER: Zeki Al Hazzouri A 

PROVIDER: S-EPMC9071443 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature