Ontology highlight
ABSTRACT:
SUBMITTER: Brahmachari S
PROVIDER: S-EPMC9071446 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Brahmachari Sumitabha S Contessoto Vinícius G VG Di Pierro Michele M Onuchic José N JN
Nucleic acids research 20220501 8
The link between genomic structure and biological function is yet to be consolidated, it is, however, clear that physical manipulation of the genome, driven by the activity of a variety of proteins, is a crucial step. To understand the consequences of the physical forces underlying genome organization, we build a coarse-grained polymer model of the genome, featuring three fundamentally distinct classes of interactions: lengthwise compaction, i.e., compaction of chromosomes along its contour, sel ...[more]