Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses.

ABSTRACT: Large-scale phenome-wide association studies performed using densely-phenotyped cohorts such as the UK Biobank (UKB), reveal many statistically robust gene-phenotype relationships for both clinical and continuous traits. Here, we present Gene-SCOUT, a tool used to identify genes with similar continuous trait fingerprints to a gene of interest. A fingerprint reflects the continuous traits identified to be statistically associated with a gene of interest based on multiple underlying rare variant genetic architectures. Similarities between genes are evaluated by the cosine similarity measure, to capture concordant effect directionality, elucidating clusters of genes in a high dimensional space. The underlying gene-biomarker population-scale association statistics were obtained from a gene-lev

SUBMITTER: Middleton L 

PROVIDER: S-EPMC9071452 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature