Use of Benzodiazepines and Risk of Incident Dementia: A Retrospective Cohort Study.

ABSTRACT:

Background

Previous findings regarding the association between benzodiazepine exposure and dementia have conflicted, though many have not accounted for anticholinergic exposure. The goal of this study was to evaluate the association of benzodiazepine exposure with the risk of developing dementia, accounting for the anticholinergic burden.

Methods

Using a retrospective cohort design, we identified veterans 65 or older without dementia during a 10-year baseline period and then followed participants for 5 years to evaluate the risk of dementia diagnosis. The primary exposure was cumulative benzodiazepine exposure. Cox proportional hazards survival model was used to examine the association between benzodiazepine exposure and dementia, adjusting for anticholinergic burden and oth

SUBMITTER: Gerlach LB 

PROVIDER: S-EPMC9071459 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature