The effects of weak selection on neutral diversity at linked sites.

ABSTRACT: The effects of selection on variability at linked sites have an important influence on levels and patterns of within-population variation across the genome. Most theoretical models of these effects have assumed that selection is sufficiently strong that allele frequency changes at the loci concerned are largely deterministic. These models have led to the conclusion that directional selection for selectively favorable mutations, or against recurrent deleterious mutations, reduces nucleotide site diversity at linked neutral sites. Recent work has shown, however, that fixations of weakly selected mutations, accompanied by significant stochastic changes in allele frequencies, can sometimes cause higher diversity at linked sites when compared with the effects of fixations of neutral mutations.

SUBMITTER: Charlesworth B 

PROVIDER: S-EPMC9071562 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature