Correlation between RASSF1A Methylation in Cell-Free DNA and the Prognosis of Cancer Patients: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Although the effects of methylation of the Ras association domain-containing protein 1 isoform A (RASSF1A) gene in cell-free DNA on the outcomes of patients with different types of cancer have been reported, the results are inconsistent.

Objective

: To explore the relationships between RASSF1A methylation in cell-free DNA and the outcomes of cancer patients.

Methods

The PubMed, Embase, and Web of Science databases were searched for papers related to this topic on December 8, 2021. The retrieved articles were screened by two independent researchers, following which the methodological quality of the selected studies was evaluated using the Newcastle-Ottawa Scale. Additionally, hazard ratios were calculated, and publication bias of the studies wa

SUBMITTER: Chen S 

PROVIDER: S-EPMC9071870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature