Synthesis and anti-phytopathogenic activity of 8-hydroxyquinoline derivatives.

ABSTRACT: Phytopathogenic fungi have become a serious threat to the quality of agricultural products, food security and human health globally, necessitating the need to discover new antifungal agents with de novo chemical scaffolds and high efficiency. A series of 8-hydroxyquinoline derivatives were designed and synthesized, and their antifungal activity was evaluated against five phytopathogenic fungi. In vitro assays revealed that most of the tested compounds remarkably impacted the five target fungi and their inhibitory activities were better than that of the positive control azoxystrobin. Compound 2, in particular, exhibited the highest potency among all the tested compounds, with an EC₅₀ of 0.0021, 0.0016, 0.0124, 0.0059 and 0.0120 mM respectively against B. cinerea<

SUBMITTER: Yin XD 

PROVIDER: S-EPMC9072087 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature