Sulfation modification of dopamine in brain regulates aggregative behavior of animals.

ABSTRACT: Behavioral plasticity and the underlying neuronal plasticity represent a fundamental capacity of animals to cope with environmental stimuli. Behavioral plasticity is controlled by complex molecular networks that act under different layers of regulation. While various molecules have been found to be involved in the regulation of plastic behaviors across species, less is known about how organisms orchestrate the activity of these molecules as part of a coherent behavioral response to varying environments. Here we discover a mechanism for the regulation of animal behavioral plasticity involving molecular sulfation in the brain, a modification of substrate molecules by sulfotransferase (ST)-catalyzed addition of a sulfonate group (SO₃) from an obligate donor, 3^'-phosphoad

SUBMITTER: Chen B 

PROVIDER: S-EPMC9072122 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature