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Formal synthesis of (+)-lactacystin from l-serine.

ABSTRACT: A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

SUBMITTER: Bulman Page PC 

PROVIDER: S-EPMC9072140 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Formal synthesis of (+)-lactacystin from l-serine.

Bulman Page Philip C PC   Goodyear Ross L RL   Chan Yohan Y   Slawin Alexandra M Z AMZ   Allin Steven M SM  

RSC advances 20190924 51

A formal, stereocontrolled synthesis of lactacystin has been completed from <i>t</i>-Bu<i>-O-</i>l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues. ...[more]

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