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Development of a fused imidazo[1,2-a]pyridine based fluorescent probe for Fe3+ and Hg2+ in aqueous media and HeLa cells.


ABSTRACT: A new fluorescent sensor 5 based on a fused imidazopyridine scaffold has been designed and synthesized via cascade cyclization. The reaction features the formation of three different C-N bonds in sequence. Imidazopyridine based fluorescent probe 5 exhibits highly sensitive and selective fluorescent sensing for Fe3+('turn-on') and Hg2+('turn-off'). The excellent selectivity of imidazopyridine for Fe3+/Hg2+ was not hampered in the presence of any of the competing cations. The limit of detection (LOD) of 5 toward Fe3+ and Hg2+ has been estimated to be 4.0 ppb and 1.0 ppb, respectively, with a good linear relationship (R 2 = 0.99). Notably, 5 selectively detects Fe3+/Hg2+ through fluorescence enhancement signalling both in vitro and in HeLa cells.

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC9072145 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Development of a fused imidazo[1,2-<i>a</i>]pyridine based fluorescent probe for Fe<sup>3+</sup> and Hg<sup>2+</sup> in aqueous media and HeLa cells.

Srivastava Suman S   Thakur Neha N   Singh Ashutosh A   Shukla Poonam P   Maikhuri Vipin Kumar VK   Garg Neha N   Prasad Ashok A   Pandey Rampal R  

RSC advances 20190920 51


A new fluorescent sensor 5 based on a fused imidazopyridine scaffold has been designed and synthesized <i>via</i> cascade cyclization. The reaction features the formation of three different C-N bonds in sequence. Imidazopyridine based fluorescent probe 5 exhibits highly sensitive and selective fluorescent sensing for Fe<sup>3+</sup>('<i>turn-on</i>') and Hg<sup>2+</sup>('<i>turn-off</i>'). The excellent selectivity of imidazopyridine for Fe<sup>3+</sup>/Hg<sup>2+</sup> was not hampered in the pr  ...[more]

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