The first report on CFTR mutations of meconium ileus in cystic fibrosis population in Saudi Arabia: A single center review.

ABSTRACT:

Introduction

Meconium ileus (MI) is one of the most common causes of intestinal obstruction in newborns. It is the earliest clinical manifestation of cystic fibrosis (CF). MI is suspected if a baby fails to pass meconium shortly after birth and develops symptoms of bowel obstruction, such as distention of the abdomen or vomiting. MI can lead to bowel perforation, a twisting of the bowel, or inflammation and infection of the abdominal cavity.

Objectives

To find the incidence and prevalence of meconium ileus in cystic fibrosis patients and to report on the most common gene mutation of MI in CF patients.

Methodology

Retrospective review of the medical documentations of all MI patients during the period of 1989-2018.

Results

A total of 40 CF confirmed patients were

SUBMITTER: Banjar H 

PROVIDER: S-EPMC9072234 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature