Opportunities and counterintuitive challenges for decentralized clinical trials to broaden participant inclusion.

ABSTRACT: Traditional clinical trials have often failed to recruit representative participant populations. Just 5% of eligible patients participate in clinical research. Participants, particularly those from minority groups, cite geographical constraints, mistrust, miscommunication, and discrimination as barriers. Here, an intersectional view of inclusion in clinical trials provides significant insights into the complex and counterintuitive challenges of trial design and participant recruitment. The US FDA have recently proposed that decentralized clinical trials (DCTs) might reduce barriers and appeal to a wider range of participants by reducing the costs and commitments required for patients to participate. While common sense and early evidence suggests that allowing participants to take part in t

SUBMITTER: Goodson N 

PROVIDER: S-EPMC9072305 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature