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Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly.

ABSTRACT: An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C-N/C-S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source.

SUBMITTER: Tian J

PROVIDER: S-EPMC9072308 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly.

Tian Jingxin J Yuan Shanshan S Xiao Fuhong F Huang Huawen H Deng Guo-Jun GJ

RSC advances 20190926 52

An efficient method for the synthesis of N-thiomethyl benzimidazoles from o-phenylenediamines, thiophenols, and aldehydes via C-N/C-S bond formation under metal-free conditions is described. A broad range of functional groups attached to the substrates were well tolerated in this reaction system. Stable and low-toxicity paraformaldehyde was used as the carbon source. ...[more]

PMID: 35530231

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