Ontology highlight
ABSTRACT:
SUBMITTER: Rhee SJ
PROVIDER: S-EPMC9072418 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Rhee Su-Jin SJ Shin Seung Han SH Oh Jaeseong J Jung Young Hwa YH Choi Chang Won CW Kim Han-Suk HS Yu Kyung-Sang KS
Scientific reports 20220505 1
Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil in term and preterm neonates with PAH, by developing a population PK model, and to suggest appropriate doses to achieve clinically effective concentrations. A population PK modelling analysis was performed using sildenafil and its metabolite N-desmethyl sildenafil (DMS) concentration data from 19 neonates with PAH, ...[more]